Cannabis extract found to have 'deadly' effect on common form of cancer

[orthene]

https://www.msn.com/en-us/health/other/cannabis-extract-found-to-have-deadly-effect-on-common-form-of-cancer/ar-BB1jGtUO?ocid=msedgdhp&pc=U531&cvid=7e2a8c4212e149878adafff5d74c662f&ei=41

Astudy has found that a cannabis extract can have a "deadly" effect on a common form of cancer. Researchers from Charles Darwin University (CDU) and the Royal Melbourne Institute of Technology (RMIT) studied PHEC-66, an extract from Cannabis sativa, and how it reacts to certain melanoma cell lines.

The study showed that the cannabis extract interacts with receptors on some melanoma cells. This suggests it could be useful as an extra treatment for malignant melanoma. However, more studies are needed to fully explore its potential and effectiveness.

Biomedical scientist Nazim Nassar from CDU said: "The damage to the melanoma cell prevents it from dividing into new cells, and instead begins a programmed cell death, also known as apoptosis."


Whether this works in a living animal body is another matter, which would need to be investigated outside of a laboratory, reports the Mirror US.

Mr Nassar added: "We know today how this extract attaches to the receptor on the cell surface and changes the messages to the inside of the cell to manipulate the normal growth, to force it to go into [a] death progress. Before we take this to human trials, we have to go through animal trials, we have to make sure that these products are safe and effective."

Researchers say they need to find a way to deliver the extract directly to the cell, possibly through a topical or subcutaneous injection under the skin.

Researchers wrote in the conclusions of the study: "We have shown that PHEC-66 impedes the growth of MM418-C1, MM329, and MM96L melanoma cells. This inhibitory effect arises from interactions with CB1 and CB2 receptors. PHEC-66's impact extends to the modulation of cell cycle progression, particularly evident in the sub G1 and sub G1/G1 phases."

"Furthermore, PHEC-66 influences metabolic pathways by inducing the accumulation of ROS within these cells, thereby tilting the balance toward pro-apoptotic signalling pathways while diminishing anti-apoptotic ones. All these actions together start the process of apoptosis and slow down the growth of melanoma cells. Further studies are required for a comprehensive understanding of its potential use in advanced-stage melanoma treatment, preferably involving more sophisticated models and assessing its viability within combination therapies."

So far, there have been no clinical trials conducted with cannabis oil and research on the cancer-fighting potential of cannabis compounds is still scant. Melanomas are cancerous cells originating from elanocytes in the epidermis.

And although melanoma represents around 6% of skin cancers, it is responsible for more than 80% of skin cancer-related deaths.

[BurnMan]

RSO aka Rick Simpson Oil was invented for skin cancer and I have seen it work.

Th gov't will continue yo have these breakthroughs as if its new news and it may help with the stigma associated with cannabis use at some point.